Slot-waveguide Analysis and Fabrication of a Planar Dielectric Waveguide

Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Any: 2014, Tutor: Mauricio Moreno SerenoWaveguides are present in many devices for communication, but this work tries to deal with their application in optical biosensing. First, a theoretical treatment is carried out with the objective to describe the demeanour of two biosensor systems, dielectric waveguide biosensor and novel waveguide geometry for enhancing and confining light named slot-waveguide. This last configuration will be explained more widely and analysing the results of different simulations. Finally, planar and rib multimode waveguides on SU8 polymer has been fabricated. Prism coupling has been used as insertion of light and, finally, the number of guided modes has been measured

Optimized PET module for both pixelated and monolithic scintillator crystals

[eng] Time-of-Flight Positron Emission Tomography (TOF-PET) scanners demand fast and efficient photo-sensors and scintillators coupled to fast readout electronics. Nowadays, there are two main configurations regarding the scintillator crystal geometry: the segmented or pixelated and the monolithic approach. Depending on the cost, spatial resolution and time requirements of the PET module, one can choose between one or another. The pixelated crystal is the most extensive configuration on TOF-PET scanners as the coincidence time resolution is better compared to the monolithic. On the contrary, monolithic scintillator crystals for Time-of-Flight Positron Emission Tomography (ToF-PET) are increasing in popularity this last years due to their performance potential and price in front of the commonly used segmented crystals. On one hand, monolithic blocks allows to determine 3D information of the gamma-ray interaction inside the crystal, which enables the possibility to correct the parallax error (radial astigmatism) at off-center positions within a PET scanner, resulting in an improvement of the spatial resolution of the device. On the other hand, due to the simplicity during the crystal manufacturing process as well as for the detector design, the price is reduced compared to a regular pixelated detector. The thesis starts with the use of HRFlexToT, an ASIC developed in this group, as the readout electronics for measurements with single pixelated crystals coupled to different SiPMs. These measurements show an energy linearity error of 3% and an energy resolution below 10% of the 511 keV photopeak. Single Photon Time Resolution (SPTR) measurements performed using an FBK SiPM NUV-HD (4 mm x 4 mm pixel size) and a Hamamatsu SiPM S13360-3050CS gave a 141 ps and 167 ps FWHM respectively. Coincidence Time Resolution (CTR) measurements with small cross-section pixelated crystals (LFS crystal, 3 m x 3 mm x 20 mm ) coupled to a single Hamamatsu SiPM S13360-3050CS provides a CTR of 180 ps FWHM. Shorter crystals (LSO:Ce Ca 0.4%) coupled to a Hamamatsu S13360-3050CS SiPM or FBK-NUVHD yields a CTR of 117 ps and 119 ps respectively. Then, the results with different monolithic crystals and SiPM sensors using HRFlexToT ASIC will be presented. A Lutetium Fine Silicate (LFS) of 25 mm x 25 mm x 20 mm, a small LSO:Ce Ca 0.2% of 8 mm x 8 mm x 5 mm and a Lutetium-Yttrium Oxyorthosilicate (LYSO) of 25 mm x 25 mm x 10 mm has been experimentally tested. After subtracting the TDC contribution (82 ps FWHM), a coincidence time resolution of 244 ps FWHM for the small LFS crystal and 333 ps FWHM for the largest LFS one is reported. Additionally, a novel time calibration correction method for CTR improvement that involves a pico-second pulsed laser will be detailed. In the last part of the dissertation, a new developed simulation framework that will enable the cross-optimization of the whole PET system will be explained. It takes into consideration the photon physics interaction in the scintillator crystal, the sensor response (sensor size, pixel pitch, dead area, capacitance) and the readout electronics behavior (input impedance, noise, bandwidth, summation). This framework has allowed us to study a new promising approach that will help reducing the CTR parameter by segmenting a large area SiPM into "m" smaller SiPMs and then summing them to recover all the signal spread along these smaller sensors. A 15% improvement on time resolution is expected by segmenting a 4 mm x 4 mm single sensor into 9 sensors of 1.3 mm x 1.3 mm with respect to the case where no segmentation is applied.[cat] Aquesta tesi tenia com a objectiu la fabricació i avaluació d'un prototip per a detecció de fotons gamma en aplicació per imatge mèdica, més concretament en Tomografia per Emissió de Positrons amb mesura de temps de vol (TOF-PET). L'avaluació del mòdul va començar fent una caracterització completa del chip (ASIC) anomenat HRFlexToT, una versió nova i millorada de l'antic chip FlexToT, desenvolupat i fabricat pel grup de la Unitat Tecnològica del ICC de la Universitat de Barcelona. Aquesta avaluació inicial del chip compren des de la comprovació de les funcionalitats bàsiques fins a la generació d'un test automàtic per generar les gràfiques de linealitat corresponents durant el test elèctric. Un cop donat per bo, es va muntar en una placa demostrada, també ideada per l'equip d'enginyers del grup, i ja quedava llesta per realitzar les mesures pertinents. Tot seguit, es varen realitzar les mesures òptiques, que incloïa mesures de Singe Photon Time Resolution (SPTR) i de Coincidence Time Resolution (CTR). Aquest valors actuen com a figures de mèrit a l'hora de comparar les prestacions amb d'altres ASICs competidors del HRFlexToT. Es van obtenir valors de 60 ps de resposta pel que respecta al SPTR i de 115 ps de CTR en cristalls segmentats, una millora entorn del 20-30% respecte a la versió predecessora del chip. Aquests valors mostren ser el límit de l'estat de l'art actual i amb aquesta idea es van començar a fer altres mesures, en aquest cas amb cristall monolítics, blocs grans llegits per diversos fotosensors de les empreses Hamamatsu i FBK. Per altra banda, es va provar el funcionament del ASIC en configuració anomenada monolítica, on el cristall centellejador s'utilitza en blocs grans en coptes d’emprar cristalls segmentats, això abarateix el cost total del detector. Aquesta configuració degrada les propietats de CTR, un paràmetre crític a l'hora de tenir un producte bo i eficient. S’han obtingut mesures de 250 ps de CTR amb aquesta configuració, d’on es pot dir que l’HRFlexToT es trobar a l’estat de l’art de la tecnologia electrònica dedicada a TOF-PET amb cristalls segmentats i monolítics. Finalment, es va desenvolupar una nova eina simulació que consisteix en un sistema híbrid entre un simulador físic i un electrònic per tal de tenir una idea del comportament complet del mòdul detector. Una solució que ningú havia provat fins ara o que no es pot trobar en la literatura

Conjugated polymers: Synthesis and applications in optoelectronics

In the last 50 years the development of conjugated polymers for applications in optoelectronics and energy has attracted great interest because of its use as conductive polymers, in solar cells or electronic devices. The continuous progress of such technology needs new polymers with suitable properties for each use. A review of the state of the art of polymer technology and the efforts for obtaining the most suitable polymers for each area is presented

Promiscuous signaling of ligands via mutant ALK2 in fibrodysplasia ossificans progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare hereditary disorder characterized by successive heterotopic bone formation, for which at present there is no therapy. Mutations in the bone morphogenetic protein (BMP) type I receptor Activin receptor-like kinase 2 (ACVR1/ALK2) are the main trigger for FOP and inflammation is thought to be the secondary hit. The single nucleotide mutation at position 617 in the cDNA ALK2 sequence, which is found in 98% of FOP patients, results in a R206H change in the intracellular juxtamembrane region of ALK2. Previous studies had revealed that this mutation perturbs the interaction with the negative regulator FKBP12, thereby sensitising cells expressing this mutant receptor to BMPs, which are potent inducers of cartilage and bone formation. Recently, however, a twist in the underlying mechanism of FOP was revealed. Mutant ALK2 was found to respond to Activin-A, whereas wild type ALK2 function is inhibited by Activin-A. The latter cytokine is induced locally upon tissue damage and inflammation. Moreover, therapeutic targeting of Activin-A was found to inhibit heterotopic ossification in a mutant ALK2 knock-in mouse model that is highly reminiscent to human FOP. This review will focus on these latest surprising findings and discuss the implication for treatment of FOP patients

Análisis de un accidente de rotura de tubos de GV mediante la utilización del SGI de Zorita

En el año 2008 la Universidad Politécnica de Madrid y la empresa Gas Natural Fenosa firmaron un acuerdo por el que se creaba el Aula José Cabrera en el Departamento de Ingeniería Nuclear de la UPM. Dicho aula cuenta con el simulador gráfico interactivo de la central nuclear José Cabrera, que es un simulador de alcance total de una central nuclear PWR de un lazo. El objetivo de la ponencia es demostrar la gran aplicación didáctica que tiene dicho aula. El simulador es una herramienta de uso interactivo para trabajo individual o en grupo con los alumnos. Dentro de la asignatura de “Fiabilidad y Análisis del Riesgo” del Máster Ciencia y Tecnología Nuclear de la ETSII-UPM, se propuso la realización de un árbol de eventos para un accidente propuesto por los alumnos. El trabajo que se presenta en esta ponencia ha consistido en el análisis del accidente de rotura de tubos en el generador de vapor usando el simulador gráfico interactivo

La captación de colesterol por Tetrahymena thermophila se realiza principalmente por fagocitosis

The free-living ciliate Tetrahymena thermophila is a unicellular model organism in which landmark biological processes have been discovered, such as the first description of telomerase activity and the molecular structure of telomeres, the mechanism of self-splicing RNA and ribozymes, the function of histone acetylation in transcription regulation and a number of pioneer experiments on the interference (RNAi) mechanism for programmed genome rearrangements, among others...Fil: Elguero, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Sánchez Granel, María Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Montes, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Cid, Nicolás Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Favale, Nicolas Octavio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Nudel, Berta Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Nusblat, Alejandro David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentin

Clustering and graph mining techniques for classification of complex structural variations in cancer genomes

For many years, a major question in cancer genomics has been the identification of those variations that can have a functional role in cancer, and distinguish from the majority of genomic changes that have no functional consequences. This is particularly challenging when considering complex chromosomal rearrangements, often composed of multiple DNA breaks, resulting in difficulties in classifying and interpreting them functionally. Despite recent efforts towards classifying structural variants (SVs), more robust statistical frames are needed to better classify these variants and isolate those that derive from specific molecular mechanisms. We present a new statistical approach to analyze SVs patterns from 2392 tumor samples from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium and identify significant recurrence, which can inform relevant mechanisms involved in the biology of tumors. The method is based on recursive KDE clustering of 152,926 SVs, randomization methods, graph mining techniques and statistical measures. The proposed methodology was able not only to identify complex patterns across different cancer types but also to prove them as not random occurrences. Furthermore, a new class of pattern that was not previously described has been identified.Among others, this study has been supported by projects: SAF2017-89450-R (TransTumVar) and PID2020-119797RB-100 (BenchSV) from Science and Innovation Spanish Minstry. It has also been supported by the Spanish Goverment (contract PID2019-107255GB), Generalitat de Catalunya (contract 2014-SGR-1051) and Universitat Politècnica de Catalunya (45-FPIUPC2018).Peer ReviewedPostprint (published version

Hierarchical algorithms for causality retrieval in atrial fibrillation intracavitary electrograms

Multi-channel intracavitary electrograms (EGMs), are acquired at the electrophysiology laboratory to guide radio frequency catheter ablation of patients suffering from atrial fibrillation (AF). These EGMs are used by cardiologists to determine candidate areas for ablation (e.g., areas corresponding to high dominant frequencies or complex fractionated electrograms). In this paper, we introduce two hierarchical algorithms to retrieve the causal interactions among these multiple EGMs. Both algorithms are based on Granger causality, but other causality measures can be easily incorporated. In both cases, they start by selecting a root node, but they differ on the way in which they explore the set of signals to determine their cause-effect relationships: either testing the full set of unexplored signals (GS-CaRe) or performing a local search only among the set of neighbor EGMs (LS-CaRe). The ensuing causal model provides important information about the propagation of the electrical signals inside the atria, uncovering wavefronts and activation patterns that can guide cardiologists towards candidate areas for catheter ablation. Numerical experiments, on both synthetic signals and annotated real-world signals, show the good performance of the two proposed approaches

Potential of Supercritical Carbon Dioxide Power Cycles to Reduce the Levelised Cost of Electricity of Contemporary Concentrated Solar Power Plants

This paper provides an assessment of the expected Levelised Cost of Electricity enabled by Concentrated Solar Power plants based on Supercritical Carbon Dioxide (sCO2) technology. A global approach is presented, relying on previous results by the authors in order to ascertain whether these innovative power cycles have the potential to achieve the very low costs of electricity reported in the literature. From a previous thermodynamic analysis of sCO2 cycles, three layouts are shortlisted and their installation costs are compared prior to assessing the corresponding cost of electricity. Amongst them, the Transcritical layout is then discarded due to the virtually impossible implementation in locations with high ambient temperature. The remaining layouts, Allam and Partial Cooling are then modelled and their Levelised Cost of Electricity is calculated for a number of cases and two different locations in North America. Each case is characterised by a different dispatch control scheme and set of financial assumptions. A Concentrated Solar Power plant based on steam turbine technology is also added to the assessment for the sake of comparison. The analysis yields electricity costs varying in the range from 8 to over 11 g/kWh, which is near but definitely not below the 6 g/kWh target set forth by different administrations. Nevertheless, in spite of the results, a review of the conservative assumptions adopted in the analysis suggests that attaining costs substantially lower than this is very likely. In other words, the results presented in this paper can be taken as an upper limit of the economic performance attainable by Supercritical Carbon Dioxide in Concentrated Solar Power applications.Unión Europea (Programa Horizonte 2020) 81498

Influence of Working Fluid Composition on the Optimum Characteristics of Blended Supercritical Carbon Dioxide Cycles

Proceedings of ASME Turbo Expo 2021: Turbomachinery Technical Conference and Exposition GT2021 June 7-11, 2021, Virtual, OnlineThe supercritical Carbon Dioxide power cycle technology has attracted growing interest from the scientific community, becoming one of the most important options currently considered for CSP applications. This is thanks to its high thermal efficiency, even at moderate turbine inlet temperatures, and small footprint. Nevertheless, sCO2 power cycles require a fairly low compressor inlet temperature to exploit their full thermodynamic potential. When this cannot be achieved, as it is usually the case for Concentrated Solar Power plants where ambient temperatures are high, the interest of the technology is compromised. To compensate for this effect, the SCARABEUS project is working on the development of certain chemical dopants that could be added to the raw CO2, obtaining new working fluids with the same or even better performance than pure CO2 even at higher minimum cycle temperatures. This paper studies the impact of using CO2 mixtures blended with Hexaflurorobenzene (C6F6) and Titanium Tetrachloride (TiCl4). It is found that these mixtures enable thermal efficiencies that are higher than if pure CO2 were used. The efficiency gain can be as high as 3 percentage points, depending on the dopant used and the operating conditions considered. In addition to this absolute performance gain, the paper reveals that there are additional degrees of freedom that enable more effective cycle optimisation. These are the dopant molar content, not only its composition, and the cycle layout used. When this is studied, it is found that the optimum molar content ranges from 10 to 20% and that the layouts of interest when using mixtures are simpler than if plain CO2 were used. These results open the way for a significant performance enhancement of Concentrated Solar Power plants.Unión Europea, Horizon 2020, Nº81498